Farmaforum 2024

26 Sept 2024 | Madrid, Spain

InvestmentUpdated on 27 August 2024

BRITE-A: Precision medicine for the treatment of obesity.

María Mengual Mesa

Innovation and Technology Transfer Manager at IBIMA Plataforma BIONAND

Málaga, Spain

About

A nanosystem consisting of a gold nanoparticle + surfactant + miRNA that acts as an anti-obesity drug and a nanosystem targeting system that allows its specific capture by adipose tissue (AT) in localized areas.

The miRNA acts on the white AT (energy storage) transforming it into beige AT (with thermogenic activity) while activating thermogenesis in both beige and brown AT (thermogenic activity).

Results

The nanosystem and the targeting system have been validated in an animal model of obesity, obtaining, among others, evidence of:

  • Decreased weight gain in animals fed a high-fat diet.

  • Overexpression of miRNA in tissue.

  • Overexpression of the thermogenesis pathway.

Stage

  • Seed and Development

Applies to

  • Biotech, Pharma and Cosmetics

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