Matchmaking Neuroscience meets Bioinformatics

4 Sept – 18 Oct 2023 | Wroclaw, Poland

Tomasz Prószyński

PI

Lukasiewicz Research Network - PORT Polish Center for Technology Development

Wrocław, Poland

6 profile visits

Our laboratory studies the Angiomotin family of proteins in the brain in the context of psychiatric disorders.

My organisation

The institute’s scientific and research endeavors are organized into three centers: ·       Life Sciences and Biotechnology (LS&BC), ·       Population Diagnostics (PDC) and ·       Material Sciences and Engineering (MS&EC). These centers house specialized Research Groups, supported by state-of-the-art measurement laboratories and core facilities. Łukasiewicz - PORT also houses a biobank, Polish National Node (PNN) of the BBMRI-ERIC network.
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About me

Amot and Yap1 regulate neuronal dendritic tree complexity and locomotor coordination in mice. Rojek KO, Krzemień J, Doleżyczek H, Boguszewski PM, Kaczmarek L, Konopka W, Rylski M, Jaworski J, Holmgren L, Prószyński TJ.PLoS Biol. 2019 May 1;17(5):e3000253. doi: 10.1371/journal.pbio.3000253


Emerging roles for angiomotin in the nervous system.
Wigerius M, Quinn D, Fawcett JP.Sci Signal. 2020 Oct 27;13(655):eabc0635. doi: 10.1126/scisignal.abc0635.

WWC1/2 regulate spinogenesis and cognition in mice by stabilizing AMOT. Cao R, Zhu R, Sha Z, Qi S, Zhong Z, Zheng F, Lei Y, Tan Y, Zhu Y, Wang Y, Wang Y, Yu FX.Cell Death Dis. 2023 Aug 1;14(8):491. doi: 10.1038/s41419-023-06020-7.


The polarity protein Angiomotin p130 controls dendritic spine maturation.
Wigerius M, Quinn D, Diab A, Clattenburg L, Kolar A, Qi J, Krueger SR, Fawcett JP.J Cell Biol. 2018 Feb 5;217(2):715-730. doi: 10.1083/jcb.201705184.

My organisation

Lukasiewicz Research Network - PORT Polish Center for Technology Development

Skills

  • mouse models
  • Angiomotins
  • synapses
  • behavior

Interests

  • neuropsychiatric disorders
  • schizophrenia
  • synapses
  • Angiomotins

Additional questions

Organization types

R&D institution

Activities

Neuroscience

Country

Poland

Participant's current Engagement in EU projects

Project idea under development Project participant searching for consortia