Ebru Ercan-Herbst
Research Group Leader
BioMed X Institute
Heidelberg, Germany
iPSC-based in vitro disease modeling. White matter deficits in schizophrenia. nucRNA-seq from post-mortem human brain.
About me
My research primarily focuses on investigating neuron-oligodendrocyte interactions and identifying the molecular mechanisms underlying myelination deficits. During my postdoctoral studies at Harvard Medical School, my work centered around autism spectrum disorders, where I discovered a neuronal factor that hinders oligodendrocyte development, leading to deficits in myelination. Over the past four years, I have been leading a team of scientists at the BioMed X Institute in Heidelberg. My research revolves around exploring early intervention strategies for schizophrenia, with a specific emphasis on the hypomyelination pathology. In pursuit of these goals, my team develops physiologically-relevant in vivo and in vitro platforms. We also employ transcriptomics analysis on post-mortem brain samples to identify potential factors contributing to hypomyelination pathology of schizophrenia.
My organisation
Skills
- iPSC
- Biochemistry
- nucRNA-seq
- cell biology
- 3D-cultures
- Disease modeling
- neuroscience
Interests
- schizophrenia
- myelination
- white matter
- iPSC models
- oligodendrocyte-neuron interaction
- Disease modeling
- 3D-cultures
- organoids
- Data Analysis
- neuroscience
Additional questions
Organization types
Activities
Country
Germany
Participant's current Engagement in EU projects