Enzyme Immobilization & Stabilization. Biomed Applications

PROOF of CONCEPT: CotA laccase.

• We produce micro/nanospheres (MS/NS) loaded with your (glyco)protein(s) of interest in any expression system (mammalian, baculovirus, bacteria).

• Easy production & cost effective: big amounts of MS/NS are easily purified. Cells do the work: express & encapsulate.

• It works at wider pH ranges than the free enzyme.

• Covalent surface modification (any desired molecule) without affecting protein activity.

1) Biomedical applications (ongoing research collaborations with Clinical research - Hospitals): i) Metabolic diseases: enzyme replacement therapy; ii) Biomarkers isolation; iii) Post-translational modifications & ubiquitin-like proteins

2) Expression of viral glycoproteins and the difficult-to-express proteins. See Scientific Reports, 2021, 11, 2802. https://doi.org/10.1038/s41598-021-82468-x

Family Patents: (1) ES2364182 B2; US10059745 B2; EP2535348 B1. (2) ES2548784 B2; EP3199636 B1; US11174485 B2. (3) P202330185 (03/03/2023).